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- Title
Assessment of the acute effects of glucocorticoid treatment on coronary microembolization using cine, first-pass perfusion, and delayed enhancement MRI.
- Authors
Jin, Hang; Yun, Hong; Ma, Jian‐ying; Chen, Zhang‐wei; Chang, Shu‐fu; Ge, Mei‐ying; Zeng, Meng‐su
- Abstract
<bold>Purpose: </bold>To assess the acute effects of methylprednisone treatment (MPT) on coronary microembolization (CME) by cardiac cine, first-pass perfusion, and delayed gadolinium enhancement magnetic resonance imaging (DE-MRI) in an experimental swine model.<bold>Materials and Methods: </bold>Microembolization was established by intracoronary infusion of microspheres into the left anterior artery. Swine received placebo (n = 12) or methylprednisolone (n = 10, 30 mg/kg) intravenously 30 minutes before microembolization. Perfusion and DE-MRI was performed 6 hours after microembolization. Cine MR images of pre-/post-CME were obtained using 1.5T scanner.<bold>Results: </bold>Cine MRI demonstrated relative amelioration of the post-CME myocardial contractile dysfunction in the glucocorticoid-treated group compared to the placebo group (P < 0.001). Post-CME target myocardial perfusion parameters decreased in both groups after microembolization. The extent of these decreases were the same for the embolized-to-control area ratio of maximum upslope (P = 0.245; 95% confidence interval of the difference [CID], -0.041/0.148) and time to peak ratio (P = 0.122; 95% CID, -0.201/0.026); however, the maximum signal intensity was higher in the glucocorticoid-treated group (P = 0.012; 95% CID, 0.023/0.156). DE-MRI revealed patchy hyperenhancement in all placebo pigs (n = 12/12) after microembolization, but no hyperenhanced regions in the glucocorticoid-pretreated pigs (n = 0/10).<bold>Conclusion: </bold>Standard, readily available, cardiac MRI techniques are useful in demonstrating post-CME myocardial dysfunction and the acute effects of glucocorticoid treatment on CME. Glucocorticoid pretreatment improves myocardial contractile dysfunction, prevents hyperenhancement, and partially ameliorates the decline of myocardial perfusion in the embolized area.
- Subjects
ANIMAL experimentation; BIOLOGICAL models; COMPARATIVE studies; CORONARY arteries; DIAGNOSTIC imaging; GLUCOCORTICOIDS; HEART; CARDIAC contraction; DIGITAL image processing; LATEX; MAGNETIC resonance imaging; RESEARCH methodology; MEDICAL cooperation; MYOCARDIAL infarction; MYOCARDIUM; PERFUSION; RESEARCH; SWINE; THERAPEUTIC embolization; EVALUATION research; METHYLPREDNISOLONE
- Publication
Journal of Magnetic Resonance Imaging, 2016, Vol 43, Issue 4, p921
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.25049