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- Title
Salivary gland function evaluated by diffusion-weighted MR imaging with gustatory stimulation: Preliminary results.
- Authors
Kato, Hiroki; Kanematsu, Masayuki; Toida, Makoto; Kawaguchi, Tomoko; Shibata, Toshiyuki; Kajita, Kimihiro; Hoshi, Hiroaki
- Abstract
Purpose: To evaluate the usefulness of diffusion-weighted MR imaging using a transient gustatory stimulation method in patients with xerostomia. Materials and Methods: Ten consecutive patients complaining of xerostomia and 10 healthy volunteers were examined with a 1.5 Tesla (T) MR unit. All study subjects completed a questionnaire, and patients underwent salivary gland scintigraphy and Saxon test. T1-, T2-, and diffusion-weighted MR images were obtained before stimulation. One minute after gustatory stimulation with lemon juice, diffusion-weighted sequence was repeated 9 times. A radiologist evaluated signal intensities and apparent diffusion coefficients (ADCs) in parotid and submandibular glands. ADC increase rate (IR) and times to maximum ADC (Tmax) were assessed. Results: IRs showed a moderate positive correlation with washout rates by scintigraphy for parotid ( r = 0.554, P < 0.05) and submandibular ( r = 0.617, P < 0.01) glands. Furthermore, Tmax values of parotid and submandibular glands were significantly higher in patients (420 ± 226 and 357 ± 232 s, respectively) than in volunteers (181 ± 68 and 200 ± 75 s, respectively) ( P < 0.01). Conclusion: Our preliminary results indicate that diffusion-weighted MR imaging using a transient gustatory stimulation method is potentially useful for evaluating patients with xerostomia. J. Magn. Reson. Imaging 2011;. © 2011 Wiley-Liss, Inc.
- Publication
Journal of Magnetic Resonance Imaging, 2011, Vol 34, Issue 4, p904
- ISSN
1053-1807
- Publication type
Article
- DOI
10.1002/jmri.22729