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- Title
Antihypothyroid Effect of Salidroside.
- Authors
Korbozova, Nazym K.; Kudrina, Nataliya O.; Zhukova, Nataliya A.; Grazhdannikov, Alexander E.; Blavachinskaya, Irina V.; Seitimova, Gulnaz A.; Kulmanov, Timur E.; Tolstikova, Tatyana G.; Terletskaya, Nina V.
- Abstract
In terms of prevalence, thyroid pathology, associated both with a violation of the gland function and changes in its structure, occupies one of the main places in clinical endocrinology. The problem of developing low-toxic and highly effective herbal preparations for the correction of thyroid hypofunction and its complications is urgent. Salidroside is a glucoside of tyrosol, found mostly in the roots of Rhodiola spp., and has various positive biological activities. The purpose of this study was to study the antihypothyroid potential of salidrosid-containing extract from R. semenovii roots, which was evaluated on a mercazolyl hypothyroidism model. We showed that extract containing salidroside is a safe and effective means of hypothyroidism correction, significantly reducing (p ≤ 0.001) the level of thyroid-stimulating hormone and increasing the level of thyroid hormones. The combined use of R. semenovii extract with potassium iodide enhances the therapeutic effect of the extract by 1.3-times.
- Subjects
POTASSIUM iodide; ENDOCRINE diseases; THYROID hormones; TREATMENT effectiveness; THYROID gland
- Publication
Molecules, 2022, Vol 27, Issue 21, p7487
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27217487