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- Title
"One-Pot" CuCl 2 -Mediated Condensation/C–S Bond Coupling Reactions to Synthesize Dibenzothiazepines by Bi-Functional-Reagent N, N′-Dimethylethane-1,2-Diamine.
- Authors
Wang, Dehe; Lu, Qichao; Li, Zhanjun; Fang, Chen; Liu, Ran; Yang, Bingchuan; Shen, Guodong
- Abstract
The efficient "One-pot" CuCl2-catalyzed C–S bond coupling reactions were developed for the synthesis of dibenzo[b,f][1,4]thiazepines and 11-methy-ldibenzo[b,f][1,4]thiazepines via 2-iodobenzaldehydes/2-iodoacetophenones with 2-aminobenzenethiols/2,2′-disulfanediyldianilines by using bifunctional-reagent N, N′-dimethylethane-1,2-diamine (DMEDA), which worked as ligand and reductant. The reactions were compatible with a range of substrates to give the corresponding products in moderate to excellent yields.
- Subjects
DIAMINES; CONDENSATION reactions; OXIDATIVE coupling
- Publication
Molecules, 2022, Vol 27, Issue 21, p7392
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27217392