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- Title
Protective Effects of Green Tea Supplementation against Lead-Induced Neurotoxicity in Mice.
- Authors
Al-Qahtani, Areej; Ajarem, Jamaan; Okla, Mohammad K.; Rubnawaz, Samina; Alamri, Saud A.; Al-Qahtani, Wahidah H.; Al-Himaidi, Ahmad R.; Elgawad, Hamada Abd; Akhtar, Nosheen; Maodaa, Saleh N.; Abdel-Maksoud, Mostafa A.
- Abstract
The use of natural products as therapeutic agents is rapidly growing recently. In the current study, we investigated the protective effects of green tea supplementation on lead-induced toxicity in mice. Forty albino mice were divided into four groups as follows: A: control group; B: green tea receiving group; C: lead-intoxicated group; and D: lead-intoxicated group supplemented with green tea. At the end of the experiment, the animals were tested for neurobehavioral and biochemical alterations. Green tea was analyzed through Gas Chromatography–Mass Spectrometry (GC/MS) analysis. We found that supplementation with green tea ameliorated the lead-associated increase in body weight and blood glucose. Green tea supplementation also changed the blood picture that was affected due to lead toxicity and ameliorated lead-induced dyslipidemia. The group of mice that were supplemented with green tea has shown positive alterations in locomotory, anxiety, memory, and learning behaviors. The GC/MS analysis revealed many active ingredients among which the two most abundant were caffeine and 1,2-benzenedicarboxylic acid, mono(2-ethylhexyl) ester. We concluded that green tea supplementation has several positive effects on the lead-induced neurotoxicity in mice and that these effects may be attributed to its main two active ingredients.
- Subjects
GREEN tea; GAS chromatography/Mass spectrometry (GC-MS); DIETARY supplements; NEUROTOXICOLOGY; EPIGALLOCATECHIN gallate; BLOOD sugar
- Publication
Molecules, 2022, Vol 27, Issue 3, p993
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27030993