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- Title
C,C- and C,N-Chelated Organocopper Compounds.
- Authors
Liu, Liang; Chen, Hui; Yang, Zhenqiang; Wei, Junnian; Xi, Zhenfeng
- Abstract
Copper-catalyzed and organocopper-involved reactions are of great significance in organic synthesis. To have a deep understanding of the reaction mechanisms, the structural characterizations of organocopper intermediates become indispensable. Meanwhile, the structure-function relationship of organocopper compounds could advance the rational design and development of new Cu-based reactions and organocopper reagents. Compared to the mono-carbonic ligand, the C,N- and C,C-bidentate ligands better stabilize unstable organocopper compounds. Bidentate ligands can chelate to the same copper atom via η2-mode, forming a mono-cupra-cyclic compounds with at least one acute C-Cu-C angle. When the bidentate ligands bind to two copper atoms via η1-mode at each coordinating site, the bimetallic macrocyclic compounds will form nearly linear C-Cu-C angles. The anionic coordinating sites of the bidentate ligand can also bridge two metals via μ2-mode, forming organocopper aggregates with Cu-Cu interactions and organocuprates with contact ion pair structures. The reaction chemistry of some selected organocopper compounds is highlighted, showing their unique structure–reactivity relationships.
- Subjects
ORGANOCOPPER compounds; CHEMICAL reactions; IONIC structure; ORGANIC synthesis; ION pairs; LIGANDS (Biochemistry); ATOMS; MACROCYCLIC compounds
- Publication
Molecules, 2021, Vol 26, Issue 19, p5806
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules26195806