We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Activity and Mechanism of Action of Antifungal Peptides from Microorganisms: A Review.
- Authors
Li, Tianxi; Li, Lulu; Du, Fangyuan; Sun, Lei; Shi, Jichao; Long, Miao; Chen, Zeliang
- Abstract
Harmful fungi in nature not only cause diseases in plants, but also fungal infection and poisoning when people and animals eat food derived from crops contaminated with them. Unfortunately, such fungi are becoming increasingly more resistant to traditional synthetic antifungal drugs, which can make prevention and control work increasingly more difficult to achieve. This means they are potentially very harmful to human health and lifestyle. Antifungal peptides are natural substances produced by organisms to defend themselves against harmful fungi. As a result, they have become an important research object to help deal with harmful fungi and overcome their drug resistance. Moreover, they are expected to be developed into new therapeutic drugs against drug-resistant fungi in clinical application. This review focuses on antifungal peptides that have been isolated from bacteria, fungi, and other microorganisms to date. Their antifungal activity and factors affecting it are outlined in terms of their antibacterial spectra and effects. The toxic effects of the antifungal peptides and their common solutions are mentioned. The mechanisms of action of the antifungal peptides are described according to their action pathways. The work provides a useful reference for further clinical research and the development of safe antifungal drugs that have high efficiencies and broad application spectra.
- Subjects
FOOD of animal origin; PEPTIDES; MEDICAL research; PLANT diseases; MICROORGANISMS; ANTIFUNGAL agents; MULTIDRUG-resistant tuberculosis
- Publication
Molecules, 2021, Vol 26, Issue 11, p3438
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules26113438