We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives.
- Authors
Gomes, Ana T. P. C.; Fernandes, Rosa; Ribeiro, Carlos F.; Tomé, João P. C.; Neves, Maria G. P. M. S.; Silva, Fernando de C. da; Ferreira, Vítor F.; Cavaleiro, José A. S.
- Abstract
Novel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of TZ-PORs as photosensitizers, the phototoxicity of the formulations towards cancer cells was screened. Biological studies show high photodynamic activity of all PVP-TZ-POR formulations against a bladder cancer cell line with a particular highlight to PVP-TZ-POR 7e and 7f that are able to significantly reduce HT-1376 cell viability, while they had no effect on control ARPE-19 cells.
- Subjects
CANCER cells; BLADDER cancer; HECK reaction; CELL survival; CELL lines; POVIDONE
- Publication
Molecules, 2020, Vol 25, Issue 7, p1607
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25071607