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- Title
Cytotoxic Activity of Inositol Angelates and Tirucallane-Type Alkaloids from Amoora Dasyclada.
- Authors
Yang, Sheng-Xiang; Song, Cheng-Gang; Kuang, Yi; Liu, Bing; Zhang, Yan-Xin; Zhang, Ming-Zhe; Zhang, Chun-Ying; Ding, Gang; Qin, Jian-Chun; De Martino, Laura
- Abstract
Three new inositol angelate compounds (1–3) and two new tirucallane-type alkaloids (4 and 5) were isolated from the Amoora dasyclada, and their structures were established mainly by means of combination of 1D and 2D nuclear magnetic resonance and HR-ESI-MS. Based on cytotoxicity testing, compounds 4 and 5 exhibited significant cytotoxic activity against human cancer cell line HepG2 with IC50 value at 8.4 and 13.2 μM. In addition, compounds 4 and 5 also showed remarkable growth inhibitory activity to Artemia salina larvae.
- Subjects
INOSITOL; NUCLEAR magnetic resonance; ANTINEOPLASTIC antibiotics; ISOQUINOLINE alkaloids; PHYTIC acid
- Publication
Molecules, 2020, Vol 25, Issue 5, p1222
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25051222