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- Title
Poly(Dopamine) Coating on 3D-Printed Poly-Lactic-Co-Glycolic Acid/β-Tricalcium Phosphate Scaffolds for Bone Tissue Engineering.
- Authors
Xu, Zhimin; Wang, Ningning; Liu, Peng; Sun, Yidan; Wang, Yumeng; Fei, Fan; Zhang, Shichen; Zheng, Jianying; Han, Bing
- Abstract
Bone defects caused by osteoporosis, bone malignant tumors, and trauma are very common, but there are many limiting factors in the clinical treatment of them. Bone tissue engineering is the most promising treatment and is considered to be the main strategy for bone defect repair. We prepared polydopamine-coated poly-(lactic-co-glycolic acid)/β-tricalcium phosphate composite scaffolds via 3D printing, and a series of characterization and biocompatibility tests were carried out. The results show that the mechanical properties and pore-related parameters of the composite scaffolds are not affected by the coatings, and the hydrophilicities of the surface are obviously improved. Scanning electron microscopy and micro-computed tomography display the nanoscale microporous structure of the bio-materials. Biological tests demonstrate that this modified surface can promote cell adhesion and proliferation and improve osteogenesis through the increase of polydopamine (PDA) concentrations. Mouse cranial defect experiments are conducted to further verify the conclusion that scaffolds with a higher content of PDA coatings have a better effect on the formation of new bones. In the study, the objective of repairing critical-sized defects is achieved by simply adding PDA as coatings to obtain positive results, which can suggest that this modification method with PDA has great potential.
- Subjects
GLYCOLIC acid; TISSUE scaffolds; THREE-dimensional printing; TISSUE engineering; SCANNING electron microscopy; PHOSPHATES; CELL adhesion; DOPAMINE
- Publication
Molecules, 2019, Vol 24, Issue 23, p4397
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules24234397