We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Two New Cytotoxic Steroidal Alkaloids from Sarcococca Hookeriana.
- Authors
Huo, Shaojie; Wu, Jichun; He, Xicheng; Pan, Lutai; Du, Jiang; D'Auria, John C.
- Abstract
Two new steroidal alkaloids, named hookerianine A (1) and hookerianine B (2) were isolated from the stems and roots of Sarcococca hookeriana Baill., along with two known compounds, sarcorucinine G (3) and epipachysamine D (4). On the basis of spectroscopic methods and by comparison with literature data, their structures were determined. As well as X-ray crystallography was performed to confirm compound 4. To identify novel antitumor inhibitors, all compounds were performed a CCK-8 assay against five human cancer cell lines SW480, SMMC-7721, PC3, MCF-7 and K562 in vitro. Compound 2 exhibited moderate cytotoxic activities to all cell lines with IC50 values in the range of 5.97–19.44 μM. Compound 3 was the most effective one against SW480 and K562 cell lines with IC50 values of 5.77 and 6.29 μM, respectively.
- Subjects
STEROIDAL alkaloids; CANCER cells; CELL lines; CELL-mediated cytotoxicity; X-ray crystallography
- Publication
Molecules, 2019, Vol 24, Issue 1, p11
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules24010011