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- Title
Four New Compounds Obtained from Cultured Cells of Artemisia annua.
- Authors
Jianhua Zhu; Peijie Xiao; Minghua Qian; Chang Chen; Chuxin Liang; Jiachen Zi; Rongmin Yu
- Abstract
Four new compounds obtained from cultured cells of Artemisia annua were reported. Products were detected by HPLC-ELSD/GC-MS and isolated by chromatographic methods. The structures of four new compounds, namely 6-hydroxy arteannuin I (1), 1-hydroxy arteannuin I (2), 2-hydroxy arteannuin J (3), and 14-hydroxy arteannuin J (4), were elucidated using their physico-chemical properties by NMR and MS data analyses. The results from the spontaneous oxidative experiment indicated that the biosynthesis of the new compounds was enzyme-catalyzed. Interestingly, the enzymes in the cultured cells of A. annua showed the abilities of substrate-selective and region-selective hydroxylation of the sesquiterpene lactone. Furthermore, the artemisinin contents were increased by 50% and 80% compared to the control group after the addition of arteannuin I/J to the suspension-cultured cells of A. annua under light and dark culture conditions, respectively.
- Subjects
ARTEMISIA annua; BIOACTIVE compounds; PLANT cell culture; HIGH performance liquid chromatography; HYDROXYLATION
- Publication
Molecules, 2017, Vol 22, Issue 12, p2264
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules22122264