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- Title
New Sesquiterpenoids and Anti-Platelet Aggregation Constituents from the Rhizomes of Curcuma zedoaria.
- Authors
Jih-Jung Chen; Tung-Han Tsai; Hsiang-Ruei Liao; Li-Chai Chen; Yueh-Hsiung Kuo; Ping-Jyun Sung; Chun-Lin Chen; Chun-Sheng Wei
- Abstract
Two new sesquiterpenoids—13-hydroxycurzerenone (1) and 1-oxocurzerenone (2)—have been isolated from the rhizomes of Curcuma zedoaria, together with 13 known compounds (3–15). The structures of two new compounds were determined through spectroscopic and MS analyses. Among the isolated compounds, 13-ydroxycurzerenone (1), 1-oxocurzerenone (2), curzerenone (3), germacrone (4), curcolone (5), procurcumenol (6), ermanin (7), curcumin (8), and a mixture of stigmast-4-en-3,6-dione (12) and stigmasta-4,22-dien-3,6-dione (13) exhibited inhibition (with inhibition % in the range of 21.28%–67.58%) against collagen-induced platelet aggregation at 100 μM. Compounds 1, 5, 7, 8, and the mixture of 12 and 13 inhibited arachidonic acid (AA)-induced platelet aggregation at 100 μM with inhibition % in the range of 23.44%–95.36%.
- Publication
Molecules, 2016, Vol 21, Issue 10, p1385
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules21101385