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- Title
One-Pot Synthesis of Novel Chiral β-Amino Acid Derivatives by Enantioselective Mannich Reactions Catalyzed by Squaramide Cinchona Alkaloids.
- Authors
Kankan Zhang; Xueping Liang; Ming He; Jian Wu; Yuping Zhang; Wei Xue; Linhong Jin; Song Yang; Deyu Hu
- Abstract
An efficient one-pot synthesis of novel β-amino acid derivatives containing a thiadiazole moiety was developed using a chiral squaramide cinchona alkaloid as organocatalyst. The reactions afforded chiral β-amino acid derivatives in moderate yields and with moderate to excellent enantioselectivities. The present study demonstrated for the first time the use of a Mannich reaction catalyzed by a chiral bifunctional organocatalyst for the one-pot synthesis of novel β-amino acid derivatives bearing a 1,3,4-thiadiazole moiety on nitrogen.
- Subjects
MANNICH reaction; MANNICH bases; AMINO acid derivatives; THIADIAZOLES; THIOUREA; CINCHONA alkaloids; NITROGEN
- Publication
Molecules, 2013, Vol 18, Issue 6, p6142
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules18066142