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- Title
Selective Growth Inhibitory Effect of Biochanin A Against Intestinal Tract Colonizing Bacteria.
- Authors
Sklenickova, Olga; Flesar, Jaroslav; Kokoska, Ladislav; Vlkova, Eva; Halamova, Katerina; Malik, Jan
- Abstract
Both bifidobacteria and clostridia are part of the natural gut microflora and while clostridia may be responsible for severe intestinal infections, bifidobacteria are probiotic microorganisms belonging to the most important prospective bacteria in the bowel. The antimicrobial activity of biochanin A was tested in vitro against six Bifidobacterium spp., and eight Clostridium spp. using the broth microdilution method. Biochanin A showed an inhibition against all clostridia in the range of minimum inhibitory concentrations (MIC) from 64 μg/mL (for Cl. clostridioforme, strains DSM 933 and I3) to 1,024 μg/mL (for Cl. perfringens, DSM 11778). No bifidobacteria were suppressed at fourfold higher concentration (MICs > 4,096) than MIC of Cl. perfringens. These results indicate selective growth inhibition of biochanin A and its potential use in antimicrobial prevention and/or protection.
- Subjects
CLOSTRIDIUM; INTESTINAL infections; BIFIDOBACTERIUM; BACILLACEAE; PROBIOTICS
- Publication
Molecules, 2010, Vol 15, Issue 3, p1270
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules15031270