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- Title
Antigenic variation of H1N1, H1N2 and H3N2 swine influenza viruses in Japan and Vietnam.
- Authors
Takemae, Nobuhiro; Nguyen, Tung; Ngo, Long; Hiromoto, Yasuaki; Uchida, Yuko; Pham, Vu; Kageyama, Tsutomu; Kasuo, Shizuko; Shimada, Shinichi; Yamashita, Yasutaka; Goto, Kaoru; Kubo, Hideyuki; Le, Vu; Vo, Hung; Do, Hoa; Nguyen, Dang; Hayashi, Tsuyoshi; Matsuu, Aya; Saito, Takehiko
- Abstract
The antigenicity of the influenza A virus hemagglutinin is responsible for vaccine efficacy in protecting pigs against swine influenza virus (SIV) infection. However, the antigenicity of SIV strains currently circulating in Japan and Vietnam has not been well characterized. We examined the antigenicity of classical H1 SIVs, pandemic A(H1N1)2009 (A(H1N1)pdm09) viruses, and seasonal human-lineage SIVs isolated in Japan and Vietnam. A hemagglutination inhibition (HI) assay was used to determine antigenic differences that differentiate the recent Japanese H1N2 and H3N2 SIVs from the H1N1 and H3N2 domestic vaccine strains. Minor antigenic variation between pig A(H1N1)pdm09 viruses was evident by HI assay using 13 mAbs raised against homologous virus. A Vietnamese H1N2 SIV, whose H1 gene originated from a human strain in the mid-2000s, reacted poorly with post-infection ferret serum against human vaccine strains from 2000-2010. These results provide useful information for selection of optimal strains for SIV vaccine production.
- Subjects
JAPAN; VIETNAM; ANTIGENIC variation; INFLUENZA A virus; H1N1 influenza; SWINE influenza; VIRUS diseases in swine
- Publication
Archives of Virology, 2013, Vol 158, Issue 4, p859
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s00705-013-1616-8