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- Title
Myelopeptides Reduce Morphine Tolerance in C57BL/6j Mice.
- Authors
Sorokina, N. S.; Starostina, M. V.
- Abstract
The development of morphine tolerance in C57BL/6j mice was estimated by the analgesic effect in tail-flick and hot plate tests. Morphine hydrochloride (10 mg/kg body weight) was administered to animals twice for 5 days and once on the sixth day, saline or myelopeptides were injected 15 min before morphine administration (2 μg/kg body weight). In the tail-flick test, all studied myelopeptides suppressed the development of tolerance to morphine and did not show their own analgesic activity. In the hot plate test, only three myelopeptides (MP2, MP5, and MP6) were found to reduce the formation of morphine tolerance. MP1 significantly reduced the analgesic effect of morphine on days 1-3 of administration, but contributed to the preservation of the analgesic effect during the period of tolerance development.
- Subjects
LABORATORY mice; ANALGESICS; MORPHINE; BODY weight
- Publication
Bulletin of Experimental Biology & Medicine, 2021, Vol 171, Issue 5, p623
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-021-05282-5