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- Title
Analysis of IL-1α, bFGF, TGF-β1, IFNγ, MMP-1, and CatD Expression in Multinuclea Macrophages <italic>In Vitro</italic>.
- Authors
Il'in, D. A.; Arkhipov, S. A.; Shkurupy, V. A.
- Abstract
The incidence of mono- and multinuclear cells and their expression of pro- and antifibrotic factors were studied in cultured peritoneal macrophages from intact and BCG-infected mice. Generally, the expression of factors increased with an increase in the number of nuclei per cell. However, the expression was higher in macrophages from BCG infected mice, except the cells with 3 and more nuclei, extremely rarely expressing IL-1α in cultures from intact and BCG-infected animals. The number of macrophages with 3 and more nuclei, expressing CatD, was comparable with the number of mono- and binuclear macrophages. Presumably, this was determined by various mechanisms of formation of multinuclear (3-5 and more nuclei) macrophages, for example, by amitosis.
- Subjects
INTERLEUKIN-1 genetics; FIBROBLAST growth factor genetics; TRANSFORMING growth factors-beta; MACROPHAGES; LABORATORY mice; BCG vaccines
- Publication
Bulletin of Experimental Biology & Medicine, 2018, Vol 164, Issue 4, p456
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-018-4011-3