We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Role of Cyclooxygenase in the Chorionic Gonadotropin Regulation of Human Neutrophil Activity.
- Authors
E. Kuklina; S. Shirshev
- Abstract
The involvement of cyclooxygenase in the regulation of the main functions of human neutrophils by chorionic gonadotropin was studied. The inhibitory effect of the hormone on phagocytosis and oxidative activity of neutrophils is completely or partially canceled under conditions of cyclooxygenase blocking. In addition, gonadotropin directly induces the expression of cyclooxygenase inducible form mRNA in these cells. These data indicate that realization of the suppressive effects of chorionic gonadotropin in the neutrophils is partially linked with activation of cyclooxygenase (both the constitutive and inducible forms of the enzyme).
- Subjects
CYCLOOXYGENASES; CHORIONIC gonadotropins; NEUTROPHILS; PHAGOCYTOSIS; PHYSIOLOGICAL oxidation; GENE expression; MESSENGER RNA; ENZYME activation
- Publication
Bulletin of Experimental Biology & Medicine, 2009, Vol 147, Issue 2, p213
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-009-0477-3