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- Title
Maternal non-steroidal anti-inflammatory drug exposure during pregnancy and risk of miscarriage: a systematic review and meta-analysis.
- Authors
Ying, Xian-hua; Bao, Dan-ni; Jiang, Hai-yin; Shi, Yu-dan
- Abstract
Background: Numerous studies have suggested that non-steroidal anti-inflammatory drugs (NSAIDs) might be associated with increased risk of miscarriage. However, these results are conflicting and inconclusive. Methods: We performed this systematic review and meta-analysis to assess the relationship between NSAIDs exposure and risk of miscarriage. A systematic literature search was conducted to identify relevant studies published from the time of database inception until June 2021. Results: A total of ten studies involving 207,341 pregnant women were subjected to meta-analysis. There was no statistically significantly increased risk of miscarriage with the use of NSAIDs during pregnancy (OR = 1.37, 95% CI 0.99–1.88, p = 0.057). However, our findings showed that women exposed to NSAIDs around the time of conception were at increased risk of miscarriage (OR 2.32, 95% CI 1.16–4.66, p = 0.018). Furthermore, no significant association between NSAID use and miscarriage was evident during the first trimester of pregnancy (OR = 1, 95% CI = 0.83–1.2, p = 0.996), possibly attributable to the small sample size. Conclusion: Our findings indicate that NSAID exposure around the time of conception might be a risk factor for miscarriage. Further studies are needed to evaluate whether the risk varies by the type, dosage, or timing of NSAID exposure.
- Subjects
RISK factors in miscarriages; ONLINE information services; META-analysis; CONFIDENCE intervals; MEDICAL information storage &; retrieval systems; NONSTEROIDAL anti-inflammatory agents; MISCARRIAGE; SYSTEMATIC reviews; HEALTH outcome assessment; ODDS ratio; MEDLINE; REPRODUCTIVE health
- Publication
European Journal of Clinical Pharmacology, 2022, Vol 78, Issue 2, p171
- ISSN
0031-6970
- Publication type
Article
- DOI
10.1007/s00228-021-03222-w