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- Title
Evolutionary paths toward multi-level convergence of lactic acid bacteria in fructose-rich environments.
- Authors
Konno, Naoki; Maeno, Shintaro; Tanizawa, Yasuhiro; Arita, Masanori; Endo, Akihito; Iwasaki, Wataru
- Abstract
Convergence provides clues to unveil the non-random nature of evolution. Intermediate paths toward convergence inform us of the stochasticity and the constraint of evolutionary processes. Although previous studies have suggested that substantial constraints exist in microevolutionary paths, it remains unclear whether macroevolutionary convergence follows stochastic or constrained paths. Here, we performed comparative genomics for hundreds of lactic acid bacteria (LAB) species, including clades showing a convergent gene repertoire and sharing fructose-rich habitats. By adopting phylogenetic comparative methods we showed that the genomic convergence of distinct fructophilic LAB (FLAB) lineages was caused by parallel losses of more than a hundred orthologs and the gene losses followed significantly similar orders. Our results further suggested that the loss of adhE, a key gene for phenotypic convergence to FLAB, follows a specific evolutionary path of domain architecture decay and amino acid substitutions in multiple LAB lineages sharing fructose-rich habitats. These findings unveiled the constrained evolutionary paths toward the convergence of free-living bacterial clades at the genomic and molecular levels. Using comparative genomics, the authors unveil constrained evolutionary paths both at genomic and molecular levels during convergent evolution of two distinct lactic acid bacteria lineages.
- Subjects
LACTIC acid bacteria; CONVERGENT evolution; COMPARATIVE genomics; STOCHASTIC convergence; COMPARATIVE method
- Publication
Communications Biology, 2024, Vol 7, Issue 1, p1
- ISSN
2399-3642
- Publication type
Article
- DOI
10.1038/s42003-024-06580-0