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- Title
Functional Aspects of Neuroprotective Effects of New Salts and Compositions of Baclofen in the Convulsive Syndrome Caused by Electroshock.
- Authors
Tyurenkov, I.; Borodkina, L.; Bagmetova, V.
- Abstract
New salts of baclofen (4-amino-3-(para-chlorophenyl)-butyric acid) and its compositions with organic carbonic acids (citric, succinic, malic, oxalic, nicotinic, glutamic acids and glycine) exhibited neuroprotective and anticonvulsive effects. They reduced the intensity of the convulsive syndrome and postconvulsive psychoneurological disorders in animals exposed to the maximum electroshock and electroconvulsive shock. Analogs of baclofen containing citrate and to a lesser extent those containing glutamate and glycine were signifi cantly more active than the initial substance.
- Subjects
BACLOFEN; SEIZURES (Medicine); CARBONIC acid; ELECTROCONVULSIVE therapy; EXPERIMENTAL pharmacology
- Publication
Bulletin of Experimental Biology & Medicine, 2012, Vol 153, Issue 5, p710
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-012-1806-5