We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Evaluation of switching from intravenous to subcutaneous formulation of tocilizumab in patients with rheumatoid arthritis.
- Authors
Naoki Iwamoto; Shoichi Fukui; Masataka Umeda; Ayako Nishino; Yoshikazu Nakashima; Takahisa Suzuki; Yoshiro Horai; Fumiaki Nonaka; Akitomo Okada; Tomohiro Koga; Shin-ya Kawashiri; Keita Fujikawa; Toshiyuki Aramaki; Kunihiro Ichinose; Yasuko Hirai; Mami Tamai; Hideki Nakamura; Kaoru Terada; Munetoshi Nakashima; Akinari Mizokami
- Abstract
Objective: To evaluate the efficacy of switching the route from intravenous tocilizumab (TCZ) infusion (TCZ-IV) to subcutaneous TCZ injection (TCZ-SC) in a real-world setting through a comparison of the clinical response. Methods: Fifty-eight rheumatoid arthritis (RA) patients, for whom TCZ-SC was initiated following TCZ-IV between June 2013 and August 2014, were consecutively enrolled. Disease activity score (DAS)28-ESR, simplified disease activity index (SDAI), and clinical disease activity index (CDAI) were examined at baseline and after switching from TCZ-IV to TCZ-SC for 3 months. We investigated whether body weight and body mass index (BMI) affected the efficacy of TCZ-SC. Results: Most of the patients had achieved remission or low disease activity at baseline (77.6% examined by DAS28). Fifty-seven patients (98%) continued the TCZ-SC treatment, and the disease activity was well controlled after 3 months. DDAS28 tended to be worsened after switching to TCZ-SC in the high-body-weight groups (-60 kg) as compared with the groups with body weight560 kg, although no statistical significance was found. BMI did not affect the efficacy of TCZ-SC. Conclusions: Caution should be exercised in the high-body-weight subjects, but these data indicate that TCZ-SC maintains the favorable RA disease activity established using TCZ-IV.
- Subjects
TOCILIZUMAB; RHEUMATOID arthritis; BODY mass index; BODY weight; SUBCUTANEOUS injections
- Publication
Modern Rheumatology, 2016, Vol 26, Issue 5, p662
- ISSN
1439-7595
- Publication type
Article
- DOI
10.3109/14397595.2015.1129692