We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
GENOTYPING OF IL13-1024 (C/T) GENE AMONG IRAQI THYROID GOITER PATIENTS.
- Authors
Jafar, Ameer M.; Hussein, Ihsan A.; Al-Assaf, Anwar I. S.; Sulaiman, Tharwat I.
- Abstract
This study dealt with IL-13 1024 (C/T) gene genotyping among patients with Thyroid goiter in Iraq. Forty blood samples from patients with Thyroid goiter were collected and compared with 30 healthy persons as controls. The genotyping results of IL-13 1024 (C/T) gene using ARMS-PCR revealed presence TT, CC and CT genotypes beside T and C alleles. The T allele and TT genotype frequency were higher in Thyroid goiter patients compared to the same genotype and allele in healthy persons (P = 0.060). These increasing results were related with increasing risk factor of Thyroid goiter (odds ratio [OR] 2.15; 95% confidence interval [CI] 0.99-71.4). No significant differences between genotypes for Thyroid goiter patients and controls were revealed by using Hardy-Weinberg distribution. In conclusion, Thyroid goiter increasing risk was related with the TT and TC genotypes and T allele and these are showed as etiological fraction (EF) with risk having Thyroid goiter, while the CC genotype ratio percentage in healthy persons was higher in comparisons with Thyroid goiter patients suggesting the CC genotype have preventive fraction (PF).
- Subjects
IRAQ; GOITER; THYROID gland; GENES; ODDS ratio; ALLELES
- Publication
Biochemical & Cellular Archives, 2022, Vol 22, Issue 1, p103
- ISSN
0972-5075
- Publication type
Article