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- Title
Tumorigenesis: Order matters.
- Authors
Seton-Rogers, Sarah
- Abstract
The article discusses the study "Effect of Mutation Order on Myeloproliferative Neoplasms," by researcher C.A. Ortmann and colleagues and published in the journal "New England Journal of Medicine," which provide evidence that the order of acquisition of two mutations in myeloproliferative neoplasms can affect tumour cell biology and clinical phenotypes. Topics discussed include impact of mutation orders in phenotypes of tumors and distributions of genotypes throughout the haematopoietic.
- Subjects
GENETIC mutation; TUMORS; MYELOPROLIFERATIVE neoplasms; ORTMANN, C. A.; NEW England Journal of Medicine, The (Periodical)
- Publication
Nature Reviews Cancer, 2015, Vol 15, Issue 4, p196
- ISSN
1474-175X
- Publication type
Article
- DOI
10.1038/nrc3926