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- Title
Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family.
- Authors
Jianming Xu; Wu, Ray-Chang; O'Malley, Bert W.; Xu, Jianming
- Abstract
The three homologous members of the p160 SRC family (SRC1, SRC2 and SRC3) mediate the transcriptional functions of nuclear receptors and other transcription factors, and are the most studied of all the transcriptional co-activators. Recent work has indicated that the SRCgenes are subject to amplification and overexpression in various human cancers. Some of the molecular mechanisms responsible for SRC overexpression, along with the mechanisms by which SRCs promote breast and prostate cancer cell proliferation and survival, have been identified, as have the specific contributions of individual SRC family members to spontaneous breast and prostate carcinogenesis in genetically manipulated mouse models. These studies have identified new challenges for cancer research and therapy.
- Subjects
CANCER treatment; GENE expression; NUCLEAR receptors (Biochemistry); TRANSCRIPTION factors; LABORATORY mice; PROTEINS; RESEARCH funding; RNA; TRANSFERASES; TUMORS
- Publication
Nature Reviews Cancer, 2009, Vol 9, Issue 9, p615
- ISSN
1474-175X
- Publication type
journal article
- DOI
10.1038/nrc2695