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- Title
Sugar-sweetened beverage but not diluted cloudy apple juice consumption induces post-prandial endotoxemia in healthy adults.
- Authors
Staltner, Raphaela; Valder, Sarah; Wodak, Maximilian F.; Köpsel, Magdalena; Herdegen, Volker; Esatbeyoglu, Tuba; Kostov, Tihomir; Diel, Patrick; Bergheim, Ina
- Abstract
Sugar beverages are discussed as critical in the development of metabolic endotoxemia. Here, employing a cross-over design study we assessed the effect of diluted cloudy apple juice (AJ), an iso-caloric and -sweetened placebo (P), or water (W) on post-prandial endotoxemia in healthy, normal weight adults. After obtaining fasting blood, 19 healthy men and women consumed 500 mL AJ, P, or W in a randomized order and blood was taken 120 and 180 min later. Caco-2 cells were incubated with the beverages. Markers of intestinal barrier function were assessed. The intake of P but not of AJ or W was associated with a significant increase in TLR2 ligands and bacterial endotoxin in serum after 120 min and 180 min, respectively. P but not AJ significantly increased bacterial toxin permeation in Caco-2 cells. Our results suggest that the effects of sugar-sweetened beverages on markers of intestinal barrier function markedly differ from those of fruit juices.
- Subjects
INTESTINAL barrier function; ENDOTOXEMIA; SOFT drinks; BACTERIAL toxins; APPLE juice; ADULTS; FRUIT juices
- Publication
NPJ Science of Food, 2024, Vol 8, Issue 1, p1
- ISSN
2396-8370
- Publication type
Article
- DOI
10.1038/s41538-024-00283-w