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- Title
Localized ulcerative nodular amyloidosis presenting as ulcerative panniculitis, an unusual clinical manifestation: A case report.
- Authors
Fernandes, Carolina; Éthier, Vincent; Marouan, Sofia; Chababi-Atallah, Myrna; Veilleux, Mylène
- Abstract
Introduction and objectives: The main objective of this article is to present and discuss a case of localized ulcerative nodular amyloidosis with deep involvement clinically manifesting as ulcerative panniculitis and discuss its impact on the choice of treatment. Methods and results: We present a 73-year-old woman with a history of painful ulcerated nodules on the inferior limbs. Microscopy confirmed amyloid deposits deep in the dermis and subcutaneous fat. No systemic involvement was found. Considering that skin-directed treatments often are not able to reach subcutaneous fat or were contraindicated because of the ulcers, she was successfully treated with cyclophosphamide and prednisone. Conclusion: Localized ulcerative nodular amyloidosis with deep involvement is a rare clinical presentation that can present as ulcerative panniculitis. Such a clinical manifestation might be misleading. Systemic treatment might be necessary to control symptoms when conventional skin-directed therapies are contraindicated.
- Publication
SAGE Open Medical Case Reports, 2019, Vol 7, pN.PAG
- ISSN
2050-313X
- Publication type
Article
- DOI
10.1177/2050313X19890755