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- Title
Effects of Matrix Metalloproteinase ( MMP)-2 Polymorphisms on Responsiveness to Antihypertensive Therapy of Women with Hypertensive Disorders of Pregnancy.
- Authors
Palei, Ana C.T.; Sandrim, Valeria C.; Amaral, Lorena M.; Machado, Jackeline S. R.; Cavalli, Ricardo C.; Lacchini, Riccardo; Duarte, Geraldo; Tanus-Santos, Jose E.
- Abstract
Imbalanced matrix metalloproteinase ( MMP) expression, including MMP-2, has been demonstrated in pre-eclampsia. However, little is known about the effect of polymorphisms in MMP-2 gene on hypertensive disorders of pregnancy. We examined whether two functional MMP-2 polymorphisms (g.-1306C>T and g.-735C>T) are associated with pre-eclampsia and/or gestational hypertension and whether these polymorphisms affect therapeutic responses in women with these conditions. We studied 216 healthy pregnant women ( HP), 185 patients with gestational hypertension ( GH) and 216 patients with pre-eclampsia ( PE). They were stratified as responsive or non-responsive to antihypertensive therapy according to clinical and laboratorial parameters of therapeutic responsiveness. Genomic DNA was extracted from whole blood and genotypes for g-1306C>T and g.-735C>T polymorphisms were determined by real-time PCR using Taqman allele discrimination assays. Haplotype frequencies were inferred using the PHASE 2.1 program. The distributions of MMP-2 genotypes and haplotypes were similar in HP, GH and PE patients ( p > 0.05). In addition, we found no significant differences in MMP-2 genotype or haplotype frequencies when GH or PE patients were classified as responsive or non-responsive to antihypertensive therapy ( p > 0.05). Our results suggest that MMP-2 polymorphisms do not affect the susceptibility to hypertensive disorders of pregnancy. In parallel, MMP-2 polymorphisms apparently do not affect the responsiveness to antihypertensive therapy of women with these hypertensive disorders of pregnancy.
- Subjects
MATRIX metalloproteinases; GENETIC polymorphisms; HYPERTENSION in women; HYPERTENSION; THERAPEUTICS; PREGNANCY complications
- Publication
Basic & Clinical Pharmacology & Toxicology, 2012, Vol 111, Issue 4, p262
- ISSN
1742-7835
- Publication type
Article
- DOI
10.1111/j.1742-7843.2012.00905.x