Haemoglobinopathies are characterised by structurally abnormal haemoglobin variants of the normal adult haemoglobin (HbA) which led to increase hemolysis and dependency on blood transfusion for maintaining normal range hemoglobin. HbD is characterized by point mutation of Glu→Gln substitution at codon 121 with a GAA→CAA change at the DNA level on chromosome number 11.