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- Title
Fused-Ring Oxazolopyrrolopyridopyrimidine Systems with Gram-Negative Activity.
- Authors
Yiyuan Chen; Moloney, Jonathan G.; Christensen, Kirsten E.; Moloney, Mark G.
- Abstract
Fused polyheterocyclic derivatives are available by annulation of a tetramate scaffold, and been shown to have antibacterial activity against a Gram-negative, but not a Gram-positive, bacterial strain. While the activity is not potent, these systems are structurally novel showing, in particular, a high level of polarity, and offer potential for the optimization of antibacterial activity.
- Subjects
ANTIBACTERIAL agents; ANNULATION; GRAM-negative bacteria; GRAM-positive bacteria; THREONINE
- Publication
Antibiotics (2079-6382), 2017, Vol 6, Issue 1, p2
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics6010002