We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Comparison of the intraocular pressure-lowering effect and safety of brimonidine/timolol fixed combination and 0.5 % timolol in normal-tension glaucoma patients.
- Authors
Kim, Joon; Kim, Tae-Woo; Kim, Chan; Kim, Hwang; Park, Ki
- Abstract
Purpose: To compare the therapeutic efficacy and safety of brimonidine/timolol fixed-combination (BTFC) and 0.5 % timolol ophthalmic solution in normal-tension glaucoma (NTG) patients. Methods: This was a multi-institution, randomized, active-controlled, open-label, parallel-group study. After a full ophthalmic and glaucoma examination, a total of 110 NTG patients-55 undergoing therapy with BTFC and 55 0.5 %, with timolol-participated in this study. Among them, 1 failed to meet the inclusion/exclusion criteria, 10 revoked their consent to participate in the study, 3 had adverse reactions, and 1 had a drug adherence rate of less than 70 %. Ultimately, a total of 95 patients-48 in the BTFC group and 47 in the 0.5 % timolol group-completed the study. The study visits took place at baseline and at 4 and 12 weeks. Diurnal IOP was measured at 9 a.m., 11 a.m., and 5 p.m. during the baseline visit and the visit at 12 weeks after eye-drop instillation. At each follow-up visit, compliance was assessed. Throughout the study, all adverse events were recorded and monitored by the investigators. Results: The average difference in IOP change measured at 11 a.m. 12 weeks after administration between the two groups was 2.10 ± 2.59 mmHg. The BTFC group had a better IOP-lowering effect at all time points than did the 0.5 % timolol group. The ratio of patients whose average IOP had decreased by >20 % after 4 and 12 weeks was 50 and 56 % in the BTFC group, respectively, whereas it was 29.41 and 23.53 % in the 0.5 % timolol group, respectively ( p = 0.034, <0.001). Conclusions: BTFC has a superior IOP-lowering effect than 0.5 % timolol in NTG patients.
- Subjects
TIMOLOL maleate; OCULAR hypertension; INTRAOCULAR pressure; HYPERTENSION; BLOOD circulation disorders; EYE diseases; GLAUCOMA; PATIENTS
- Publication
Japanese Journal of Ophthalmology, 2016, Vol 60, Issue 1, p20
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-015-0420-2