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- Title
Clinical and histopathological features of a suspected case of fish-eye disease.
- Authors
Tateno, Hiroko; Taomoto, Makoto; Jo, Nobuo; Takahashi, Kanji; Uemura, Yoshiko
- Abstract
Purpose: To report the clinical and histopathological features of a suspected case of fish-eye disease. Case: A 57-year-old man presented with blurred vision. The best corrected visual acuity was 0.8 OD and 1.0 OS. The patient had no family history of cloudy cornea. Slit-lamp examination revealed massive bilateral diffuse corneal clouding. Because of progressive corneal clouding during the previous 3 years, we performed penetrating keratoplasty and cataract surgery. He had a low-plasma, high-density lipoprotein (HDL) concentration. Histopathologically, numerous small vacuoles were dispersed, especially in the anterior corneal stroma. An electron microscope revealed distinct 0.2-3.0-μm lipid vacuoles with a conserved stromal structure. Conclusion: We suspected a case of sporadic fish-eye disease in a Japanese patient. Lipid deposition needs to be considered as a cause of diffuse corneal opacity.
- Subjects
EYE diseases; VISION disorders; VISUAL acuity; CORNEA diseases; CATARACT surgery
- Publication
Japanese Journal of Ophthalmology, 2012, Vol 56, Issue 5, p453
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-012-0164-1