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- Title
Impact of photodynamic therapy on quality of life of patients with age-related macular degeneration in Korea.
- Authors
Kim, Jinhyun; Kwak, Hyung; Lee, Won; Kim, Ha
- Abstract
To assess quality of life (QOL) changes in patients with age-related macular degeneration (AMD) before and after treatment with photodynamic therapy (PDT). In 625 patients with AMD, the EuroQol Health Questionnaire (EQ-5D) for general health status and the Visual Function Questionnaire (VF-4D) for vision-related reading ability, independence, and fear for the future were used and the results compared between within 1 week before PDT and 1 year after PDT. Subscale QOL changes were also scored with the Korean versions of EQ-5D and VF-4D. EQ-5D scores of male patients were higher than those of female patients ( P < 0.05), and scores of unilateral patients were higher than those of bilateral patients ( P < 0.001). Among all patients, 41.2% had a higher EQ-5D score after PDT. The mean differences between before and after treatment, estimated by three different models, the Korean model, the UK model, and the Japanese model, were all statistically significant ( P < 0.001). Utility measured by the VF-4D score after PDT increased by 16.1% ( P < 0.001), and subscale utilities indicated significant improvements in fear for the future (21.1%), reading ability (16.6%–14.5%), and independence (11.6%). PDT for patients with AMD improved both general health-related QOL and vision-related QOL, as well as subscale scores, as evaluated by EQ-5D and VF-4D.
- Subjects
KOREA; PHOTOCHEMOTHERAPY; QUALITY of life; AGE factors in retinal degeneration; PHOTOSENSITIZERS; HEALTH surveys; HEALTH status indicators; OPHTHALMOLOGY
- Publication
Japanese Journal of Ophthalmology, 2010, Vol 54, Issue 4, p325
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-010-0825-x