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- Title
Optical coherence tomographic evaluation of the outer retinal architecture in Oguchi disease.
- Authors
Kisaburo Yamada; Yuka Motomura; Celso Matsumoto; Kazuo Nakatsuka
- Abstract
Abstract Background  To report the changes in the optical coherence tomography (OCT) images of the outer retinal layers after prolonged dark adaptation in a patient with Oguchi disease. Case  A 75-year-old woman showed the typical golden-yellow fundus reflex of Oguchi disease, and the coloration returned to normal after prolonged dark adaptation. Fourier domain OCT (FD-OCT) was performed on the patientâs left eye before and after prolonged dark adaptation. Observations  Before dark adaptation, the FD-OCT images at the fovea had three identifiable reflection bands, namely, the external limiting membrane (ELM), the border between the photoreceptor inner and outer segments (IS/OS line), and the retinal pigment epithelium (RPE)/Bruch band. The paramacular area had only the ELM and RPE/Bruch bands. After 4 h of dark adaptation, the IS/OS line was also detected in the paramacular area. Conclusions  The absence of the IS/OS line in the extramacular regions in the partly dark adapted condition was most likely due to a defect in the rod photoreceptors of this area. The emergence of the IS/OS line after prolonged dark adaptation suggests that microarchitectural changes occur in the photoreceptors and that the changes may be correlated with the improvement of rod function.
- Subjects
OPTICAL coherence tomography; RETINAL (Visual pigment); FUNDUS oculi; NIGHT vision; PHOTORECEPTORS; EPITHELIUM; RHODOPSIN; EYE diseases
- Publication
Japanese Journal of Ophthalmology, 2009, Vol 53, Issue 5, p449
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-009-0708-1