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- Title
Effect anti-osteoporotic drugs on the bone homeostasis of bone and glucose metabolism in patients with glucocorticoid-induced osteoporosis.
- Authors
HUANG Yonghui; LONG Enwu; WANG Chuanwei; CHEN Lujia; JIANG Xuehua; WANG Ling
- Abstract
Objective To investigate the effects of anti-osteoporotic on glucose homeostasis in patients with glucocorticoid-induced osteoporosis. Methods Patients with osteoporosis who met the inclusion criteria (n = 122) in our hospital between August 2009 and August 2012 were recruited. They were divided into alendronate group (A), teriparatide group (B), and calcium and vitamin D group (C) randomly. Blood glucose levels (FBG and HbAlc) and bone turnover levels (β-CTX and OC) were compared and analyzed before and after the treatment. Results OC value was below the reference range in 32 patients (26.2% ) at the initial time of the study. Fifty-six patients (45.9%) were diagnosed as glucose tolerance disorder or diabetes mellitus according to their initial blood glucose level. The level of FBG (5.2 ± 0.8 mmol/L) in B group after 1-year treatment was significant lower than that before the treatment (5.6 ± 1.0 mmol/L, P = 0.049). In B group, the level of HbAlc (5.3 ± 1.0%) after 1-year treatment was significant lower than that before the treatment experiment (5.9 ± 1.3%, P =0.021). The ratio of impaired glucose tolerance in patients and diabetes mellitus decreased significantly (24.3% to 7. 3%, P =0.033 ; 21.9% to 4.8%, P =0.023, respectively). β-CTX level after 6 months and 1 year treatment was significantly lower than that before the treatment in A, B, and C group (p < 0. 05), but OC level was higher (p < 0.05). OC level in B group (16.4 ± 0.9 µg/l) was higher than that in group A (15.9 ± 1.1 µg/1) and C (15. 7 ± 0. 9 µg/l) after 1-year treatment (P = 0.027 and P = 0. 001, respectively). Conclusion The anti-osteoporotic bone-anabolic drug teriparatide may affect glucose metabolism in patients with glucocorticoid- induced osteoporosis. But more studies are needed to provide more evidence.
- Publication
Chinese Journal of Osteoporosis, 2015, Vol 21, Issue 5, p564
- ISSN
1006-7108
- Publication type
Article
- DOI
10.3969/j.issn.1006-7108.2015.05.010