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- Title
Cerebellar ataxia and primary Sjogren's syndrome without cerebellar degeneration: a case report.
- Authors
Lira e Silva, Maria Júnia; Magalhães, João Eudes
- Abstract
This article reports on a case of an 86-year-old woman with primary Sjogren's syndrome (pSS) who presented with cerebellar ataxia, despite no abnormalities on magnetic resonance imaging (MRI). Cerebellar ataxia is a rare manifestation of pSS, occurring in only 1.5% of cases, and is typically accompanied by cerebellar atrophy on MRI. The patient was diagnosed with pSS based on clinical symptoms, positive Sjogren's antibodies, and an elevated erythrocyte sedimentation rate. Treatment with intravenous methylprednisolone and cyclophosphamide resulted in clinical improvement. The article also discusses other reported cases of cerebellar ataxia in pSS without cerebellar degeneration on MRI and the possible inflammatory mechanisms involved in the pathogenesis of cerebellar involvement in pSS.
- Subjects
SJOGREN'S syndrome; CEREBELLAR ataxia; CEREBELLUM degeneration; TREMOR; MAGNETIC resonance imaging; ESSENTIAL tremor; CEREBROSPINAL fluid
- Publication
Neurological Sciences, 2024, Vol 45, Issue 6, p2919
- ISSN
1590-1874
- Publication type
Article
- DOI
10.1007/s10072-024-07333-x