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- Title
Prognostic Value of Routine Biomarkers in the Early Stage of COVID-19.
- Authors
Mihajlović, Andrea; Ivanov, David; Tapavički, Borislav; Marković, Milica; Vukas, Dragana; Miljković, Ana; Bajić, Dejana; Semnic, Isidora; Bogdan, Maja; Karaba Jakovljević, Dea; Nikolić, Stanislava; Slavić, Danijel; Lendak, Dajana
- Abstract
Various biomarkers like certain complete blood cell count parameters and the derived ratios including neutrophil–lymphocyte ratio are commonly used to evaluate disease severity. Our study aimed to establish if baseline levels of complete blood cell count-derived biomarkers and CRP, measured before any treatment which can interfere with their values, could serve as a predictor of development of pneumonia and the need for hospitalization requiring oxygen therapy. We retrospectively analyzed the laboratory data of 200 consecutive patients without comorbidities, who denied usage of medications prior to blood analysis and visited a COVID-19 ambulance between October and December 2021. Multivariate regression analysis extracted older age, elevated CRP and lower eosinophil count as significant independent predictors of pneumonia (p = 0.003, p = 0.000, p = 0.046, respectively). Independent predictors of hospitalization were higher CRP (p = 0.000) and lower platelet count (p = 0.005). There was no significant difference in the neutrophil–lymphocyte and platelet–lymphocyte ratios between examined groups. Individual biomarkers such as platelet and eosinophil count might be better in predicting the severity of COVID-19 than the neutrophil–lymphocyte and platelet–lymphocyte ratios.
- Subjects
PNEUMONIA diagnosis; RISK factors of pneumonia; PNEUMONIA treatment; BIOMARKERS; C-reactive protein; EOSINOPHILS; COVID-19; PLATELET lymphocyte ratio; CHEST X rays; CONFIDENCE intervals; MULTIVARIATE analysis; RETROSPECTIVE studies; ACQUISITION of data; REGRESSION analysis; MANN Whitney U Test; SEVERITY of illness index; NEUTROPHIL lymphocyte ratio; RISK assessment; HOSPITAL care; OXYGEN therapy; MEDICAL records; RESEARCH funding; ROUTINE diagnostic tests; BLOOD cell count; DATA analysis software; RECEIVER operating characteristic curves; ODDS ratio; COMORBIDITY
- Publication
Healthcare (2227-9032), 2023, Vol 11, Issue 15, p2137
- ISSN
2227-9032
- Publication type
Article
- DOI
10.3390/healthcare11152137