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- Title
Cross-sectional and Prospective Associations of Rest-Activity Rhythms With Metabolic Markers and Type 2 Diabetes in Older Men.
- Authors
Xiao, Qian; Qian, Jingyi; Evans, Daniel S.; Redline, Susan; Lane, Nancy E.; Ancoli-Israel, Sonia; Scheer, Frank A.J.L.; Stone, Katie; Osteoporotic Fractures in Men (MrOS) Study Group
- Abstract
<bold>Objective: </bold>Disruption of rest-activity rhythms is cross-sectionally associated with metabolic disorders, including type 2 diabetes, yet it remains unclear whether it predicts impaired glucose metabolism and homeostasis. The aim of this study is to examine the cross-sectional and prospective associations between rest-activity rhythm characteristics and glycemic measures in a cohort of older men.<bold>Research Design and Methods: </bold>Baseline rest-activity rhythms were derived from actigraphy with use of extended cosine model analysis. With subjects fasting, glucose, insulin, and HOMA of insulin resistance (HOMA-IR) were measured from blood at baseline and after ∼3.5 years. Type 2 diabetes was defined based on self-report, medication use, and fasting glucose.<bold>Results: </bold>In the cross-sectional analysis (n = 2,450), lower 24-h amplitude-to-mesor ratio (i.e., mean activity-adjusted rhythm amplitude) and reduced overall rhythmicity were associated with higher fasting insulin and HOMA-IR (all Ptrend < 0.0001), indicating increased insulin resistance. The odds of baseline type 2 diabetes were significantly higher among those in the lowest quartile of amplitude (Q1) (odds ratio [OR]Q1 vs. Q4 1.63 [95% CI 1.14, 2.30]) and late acrophase group (ORlate vs. normal 1.46 [95% CI 1.04, 2.04]). In the prospective analysis (n = 861), multiple rest-activity characteristics predicted a two- to threefold increase in type 2 diabetes risk, including a lower amplitude (ORQ1 vs. Q4 3.81 [95% CI 1.45, 10.00]) and amplitude-to-mesor ratio (OR 2.79 [95% CI 1.10, 7.07]), reduced overall rhythmicity (OR 3.49 [95% CI 1.34, 9.10]), and a late acrophase (OR 2.44 [1.09, 5.47]).<bold>Conclusions: </bold>Rest-activity rhythm characteristics are associated with impaired glycemic metabolism and homeostasis and higher risk of incident type 2 diabetes.
- Subjects
TYPE 2 diabetes; OLDER men; RHYTHM; METABOLIC disorders; INSULIN resistance; FASTING; RESEARCH; CROSS-sectional method; RESEARCH methodology; BLOOD sugar; ACTIGRAPHY; MEDICAL cooperation; EVALUATION research; RELAXATION for health; INSULIN; COMPARATIVE studies; EXERCISE; LONGITUDINAL method
- Publication
Diabetes Care, 2020, Vol 43, Issue 11, p2702
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc20-0557