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- Title
Are Adverse Reproductive Outcomes Associated With the Illness or Its Treatment (or Both)?
- Authors
Wisner, Katherine L.; Yonkers, Kimberly A.
- Abstract
Pregnancy stress and stress-associated disorders are linked to adverse birth outcomes.[2] Long-term disturbances in hypothalamic-pituitary-adrenal axis function that may underlie the heightened vulnerability to adverse birth outcomes and offspring psychopathology have been reported.[3] Psychiatric diagnoses are underreported yet likely to be higher in the benzodiazepine group, which leads to residual confounding.[4] Substance misuse and use disorders are particularly vulnerable to underreporting because of stigma attached to these conditions. While the authors' reported E-value for the association between benzodiazepine exposure and miscarriage was favorable, caution in interpreting its accuracy when quantifying residual confounding is recommended.[5].
- Subjects
DISEASES; MISCARRIAGE; BENZODIAZEPINES; TRANQUILIZING drugs; PREGNANCY outcomes
- Publication
JAMA Psychiatry, 2019, Vol 76, Issue 12, p1317
- ISSN
2168-622X
- Publication type
letter
- DOI
10.1001/jamapsychiatry.2019.2445