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- Title
The Relationship of CSF-1 and Its Receptor with Early Spontaneous Abortion.
- Authors
HU Ji-lin; SUN Jian-jun; LI Shu-de; BAI Qin; LUO Fang; YUE Hong-ping
- Abstract
Objective To investigate the relationship of Maternal-fetal interface local cytokine CSF-1 and its receptors with the occurrence of the early spontaneous abortion. Methods From August 2009 to December 2011, we collected 30 villi tissue samples with artificial abortion and 30 villi tissue samples with spontaneous abortion. At the same time, we collected 30 villi tissue samples with artificial abortion and 30 decidua tissue samples with spontaneous abortion, and 30 decidua tissue samples with spontaneous abortion. The human chorionic gonadotropin (HCG) was detected by radioimmunoassay in each group. The expressions of colony Stimulating Factor 1 (CSF-l) and colony Stimulating Factor 1 receptor ( CSF-1 R ) were detected by Immunohistochemical staining and Western Blot in the villi tissue and decidua tissue in every group. Results The levels of HCG in the spontaneous abortion group were lower than those in the artificial abortion group ( P < 0.05) . The protein expression of CSF-1 and CSF-1 R about the artificial abortion and spontaneous abortion in the the spontaneous abortion group were found. The protein expression levels of CSF-1 and CSF-1 R about the artificial abortion and spontaneous abortion in the the spontaneous abortion group were higher than the artificial abortion group by immunohistochemical staining and Western Blot (P<0.05) . Conclusions The right concentrations of CSF-1 and CSF-1R maintain the pregnancy continued. However, The higher concentrations of CSF-1 and CSF-1 R may be one of the factors leading to spontaneous abortion.
- Subjects
COLONY-stimulating factors (Physiology); ABORTION research; CYTOKINES; CHORIONIC gonadotropins; PREGNANCY complications
- Publication
Journal of Kunming Medical University / Kunming Yike Daxue Xuebao, 2014, Vol 35, Issue 8, p114
- ISSN
2095-610X
- Publication type
Article