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- Title
Effects of atrovastatin on concentrations of 3-hydroxy-3-methyl-glutaryl-coenzyme A- reductase (HMG-CoA-R), proprotein convertase subtilisin/kexin type 9 (PCSK9) and sortilin in patients with type 2 diabetes mellitus and pre-diabetics.
- Authors
Andevari, Ali Nosrati; Moein, Soheila; Qujeq, Durdi; Moazezi, Zoleika; Tilaki, Karimollah Hajian
- Abstract
Introduction: Atorvastatin hinders cardiovascular disease by reducing cholesterol levels. Proprotein convertase subtilisin/kexin type 9 (PCSK9) enhances the secretion of insulin by binding to LDL-receptor. Sortilin is committed in the transfer of intracellular proteins through the plasma membrane. Objectives: The purpose of this research was to determine the effect of atorvastatin consumption on alterations in the levels of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA-R), PCSK9 and sortilin in diabetic patients and pre-diabetics. Patients and Methods: This study was carried out on 80 individuals including normal subjects, diabetic patients and pre-diabetics. The participated individuals were divided as control group (i) (healthy individuals without diabetes mellitus), diabetic group receiving statin (ii), diabetic group not receiving statin (iii), pre-diabetic group receiving statin (iv) and pre-diabetic group not receiving statin (v). Levels of HMG-COA-R, PCSK9 and sortilin were determined by ELISA method. Results: In diabetics and pre-diabetics taking atorvastatin, the level of HMG-COA-R was not altered significantly compared to diabetics and pre-diabetics not taking atorvastatin, respectively (P > 0.05). The serum PCSK9 level in diabetics and pre-diabetics was significantly higher than the healthy individuals (P = 0.001). Additionally, the serum PCSK9 level in diabetics and pre-diabetics receiving atorvastatin was significantly higher than diabetics and pre-diabetics not receiving atorvastatin, respectively (P = 0.001). The serum sortilin level in diabetics and pre-diabetics was significantly higher than the healthy individuals (P = 0.001). In addition, the serum sortilin level in pre-diabetics receiving atorvastatin was significantly higher than pre-diabetics not receiving atorvastatin (P = 0.001). Conclusion: Atorvastatin improved insulin secretion and sensitivity by increasing serum sortilin and PCSK9 levels. Thereby, it prevented the development of diabetes in diabetics and the progression of pre-diabetes to diabetes in pre-diabetics.
- Subjects
TYPE 2 diabetes; SUBTILISINS; PEOPLE with diabetes; SORTILIN; ATORVASTATIN
- Publication
Journal of Nephropathology, 2021, Vol 10, Issue 1, p1
- ISSN
2251-8363
- Publication type
Article
- DOI
10.34172/jnp.2021.05