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- Title
Correlation between first-trimester maternal serum markers, second-trimester uterine artery doppler indices and pregnancy outcome.
- Authors
Dane, Banu; Dane, Cem; Kiray, Murat; Cetin, Ahmet; Koldas, Macit; Erginbas, Murat
- Abstract
<bold>Aims: </bold>The aim of this study was to assess the correlation between first trimester maternal serum free beta-human chorionic gonadotropin (fBHCG), pregnancy-associated plasma protein A (PAPPA), second-trimester uterine artery (UA) Doppler measurements and adverse pregnancy outcomes. <bold>Methods: </bold>Serum levels of PAPPA and fBHCG were determined at the first trimester, and patients underwent bilateral UA Doppler assessments at 20-25 weeks of gestation. A serum PAPPA level <0.4 MoM was termed as low and the abnormal Doppler findings were the presence of bilateral notches and RI >0.52 (mean) or unilateral notch and RI >0.66 (90th percentile). <bold>Results: </bold>Mean PAPPA level was significantly lower in cases with unilateral or bilateral notches (1.09; 0.79 and 0.80 MoM for 0, 1 and 2 notches, p < 0.001). Fifty-two cases (12.8%) had a low PAPPA level; in this group the incidence of abnormal Doppler was significantly higher (34.6 vs. 18.4%, p = 0.011). In the presence of abnormal Doppler in a case with a low serum PAPPA the risk of pregnancy-induced hypertension (OR = 4.56, p = 0.0067), low birth weight (OR = 6.8, p = 0.0002) and the risk of at least one complication (OR = 7.6, p = 0.00001) were significantly high. <bold>Conclusion: </bold>Combination of first- and second-trimester findings might improve the efficiency of screening for pregnancy complications.
- Subjects
CHORIONIC gonadotropins; FIRST trimester of pregnancy; SECOND trimester of pregnancy; DOPPLER effect; ARTERIES; HYPERTENSION in pregnancy
- Publication
Gynecologic & Obstetric Investigation, 2010, Vol 70, Issue 2, p126
- ISSN
0378-7346
- Publication type
journal article
- DOI
10.1159/000303260