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- Title
<em>In vivo</em> effects of interferon-γand anti-interferon- γantibody on the experimentally induced lichenoid tissue reaction.
- Authors
Shiohara, T.; Nickoloff, B.J.; Moriya, N.; Gotoh, C.; Nagashima, M.
- Abstract
We investigated the in vivo effect of recombinant interferon-γ (IFN-γ) and tumour necrosis factor α (TNF-α) treatment of mice on the development of the delayed-type hypersensitivity (DTH) reaction and lichenoid tissue reaction (LTR) following the local injection of cloned autoreactive T cells. Both the DTH reaction and the LTR were significantly enhanced by pre- treatment with IFN-γ, but not with TNF-α. Induction of class II MHC antigens on keratinocytes was not essential for the enhancement by IFN-γ. Administration of anti-IFN-γ antibody reduced the DTH reaction and LTR, although complete inhibition was not observed with our treatment regimen. The ability of I FN-γ to increase the number of the cloned T cells invading the epidermis in vivo, is in keeping with our previous observation that IFN-γ treatment of cultured keratinocytes markedly increased the adherence reaction between T cells and keratinocytes in vitro.
- Subjects
INTERFERONS; TUMOR necrosis factors; DELAYED hypersensitivity; T cells; KERATINOCYTES; DERMATOLOGY
- Publication
British Journal of Dermatology, 1988, Vol 119, Issue 2, p199
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1988.tb03202.x