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- Title
N,O‐Nucleoside Analogues: Metabolic and Apoptotic Activity.
- Authors
Marraffa, Andrea; Presenti, Piero; Macchi, Beatrice; Marino‐Merlo, Francesca; Mella, Mariella; Quadrelli, Paolo
- Abstract
Two new families of N,O‐nucleoside analogues containing the anthracene moiety introduced through the nitrosocarbonyl ene reaction with allylic alcohols were prepared. The core structure is an isoxazolidine heterocycle that introduces either atom either a phenyl ring or dimethyl moiety at the C3 carbon. Different heterobases were inserted at the position 5 of the heterocyclic ring. One of the synthesized compounds demonstrated a good capacity to induce cell death and an appreciable nuclear fragmentation was evidenced in treated cells.
- Subjects
ENE reactions; NUCLEAR fragmentation; CELL death; ALLYL alcohol; APOPTOSIS; ALLYLIC amination
- Publication
ChemistryOpen, 2020, Vol 9, Issue 5, p528
- ISSN
2191-1363
- Publication type
Article
- DOI
10.1002/open.202000034