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- Title
The Regulation Network and Clinical Significance of Circular RNAs in Breast Cancer.
- Authors
Xu, Juan; Chen, Xiyi; Sun, Yu; Shi, Yaqian; Teng, Fang; Lv, Mingming; Liu, Chen; Jia, Xuemei
- Abstract
Breast cancer is one of the most common malignant tumors in women worldwide. Circular RNA (circRNA) is a class of structurally stable non-coding RNA with a covalently closed circular structure. In recent years, with the development of high-throughput RNA sequencing, many circRNAs have been discovered and have proven to be clinically significant in the development and progression of breast cancer. Importantly, several regulators of circRNA biogenesis have been discovered. Here, we systematically summarize recent progress regarding the network of regulation governing the biogenesis, degradation, and distribution of circRNAs, and we comprehensively analyze the functions, mechanisms, and clinical significance of circRNA in breast cancer.
- Subjects
CIRCULAR RNA; BREAST cancer; RNA sequencing; NON-coding RNA; CANCER invasiveness
- Publication
Frontiers in Oncology, 2021, Vol 11, p1
- ISSN
2234-943X
- Publication type
Article
- DOI
10.3389/fonc.2021.691317