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- Title
Electrochemical lactonization of trisialic acid.
- Authors
Chen, Chien‐Sheng; Xu, Lai; Lee, Wei‐Jen
- Abstract
A sensitive method using high‐performance capillary electrophoresis (HPCE) is employed to study the electrochemical lactonization of α2,8‐trisialic acid. Analysis shows that the sialyl lactonization of trisialic acid in an acidic aqueous solution (pH 4.2–6) is highly enhanced by a supporting electrical current (30–100 μA). CE results indicate that this electrochemical lactonization with a supporting current is faster than the acid‐catalyzed lactonization in acetic acid. This acceleration in the reaction suggests that the acidity increases close to the Pt electrode and assists the sialyl lactonization during electrolysis. Three lactone species of trisialic acid formed in the acidic aqueous solution were detected with HPCE, and the fully lactonized species were examined with time‐of‐flight mass spectrometry and NMR spectroscopy. The elution order of the lactone isomers obtained from previous report and from this study together reveals a regioselective lactoziation in which the sialyl residue close to the reducing end was more reactive than that close to the nonreducing end. Sialyl lactonization of trisialic acid was promoted with an electrochemical current in acidic aqueous solution and analyzed by capillary electrophoresis. Present data shows that this electrochemical lactonization is faster than acid‐catalyzed lactonization in acetic acid.
- Subjects
ELECTROCHEMISTRY; SIALIC acids; CAPILLARY electrophoresis; AQUEOUS solutions; ACETIC acid; PLATINUM electrodes
- Publication
Journal of the Chinese Chemical Society, 2018, Vol 65, Issue 10, p1245
- ISSN
0009-4536
- Publication type
Article
- DOI
10.1002/jccs.201800080