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- Title
Age at Menarche and Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study Among 27,482 Women.
- Authors
Liwei Chen; Shanshan Li; Chunyan He; Yeyi Zhu; Louis, Germaine M. Buck; Yeung, Edwina; Hu, Frank B.; Cuilin Zhang; Chen, Liwei; Li, Shanshan; He, Chunyan; Zhu, Yeyi; Buck Louis, Germaine M; Zhang, Cuilin
- Abstract
<bold>Objective: </bold>To examine the association between age at menarche and risk of gestational diabetes mellitus (GDM).<bold>Research Design and Methods: </bold>A prospective cohort study of 42,109 eligible pregnancies from 27,482 women in the Nurses' Health Study II.<bold>Results: </bold>The adjusted risk ratios for GDM across the age at menarche categories (≤11, 12, 13, and ≥14 years) were 1.34 (95% CI 1.14-1.58), 1.13 (0.97-1.31), 1.11 (0.95-1.29), and 1.00 (referent; P for trend = 0.0005), respectively. Analysis of the mediating effect indicated that 42.1% (P = 0.0007) of the association was mediated through prepregnancy BMI.<bold>Conclusions: </bold>These findings suggested that earlier menarche was significantly associated with an increased risk of GDM. This association was largely mediated through prepregnancy excessive body adiposity.
- Subjects
GESTATIONAL diabetes; MENARCHE; PREGNANCY complications; FAT; ENDOCRINOLOGY; DISEASE risk factors; OBESITY complications; ADIPOSE tissues; AGE distribution; HUMAN body composition; LONGITUDINAL method; RESEARCH funding; ODDS ratio
- Publication
Diabetes Care, 2016, Vol 39, Issue 3, p469
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc15-2011