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- Title
Mercury: Its role in endoplasmic reticulum stress of pancreatic beta cells in the incident of diabetes mellitus.
- Authors
Shni, Hazim Mohammed; Hussein, Abdulameer M.; jabber, Sabah N.
- Abstract
Oxidative stress induced by mercury can cause an inflammatory state in cells that results in cell damage. Free radical formation and decreased antioxidant defences create an imbalance that contributes to the incidence of diabetes mellitus. Mercury as a free radical agent targets its action on pancreatic beta cells and causes defects in these cells resulting in abnormalities in insulin secretion as the pathophysiological basis of diabetes is closely related to apoptosis and necrosis through oxidative stress pathways. One of the components of pancreatic beta cells that mercury targets to cause defects is the endoplasmic reticulum. The role of endoplasmic reticulum in pancreatic beta cells as an intracellular calcium store not only regulates cytosolic calcium signalling but also the conformation of protein folds, so if there is a defect in endoplasmic reticulum homeostasis, known as endoplasmic reticulum stress, it is an early event in the pathophysiology of diabetes mellitus.
- Subjects
PANCREATIC beta cells; ENDOPLASMIC reticulum; DIABETES; MERCURY; PROTEIN conformation; INTRACELLULAR calcium; CALCIUM channels; PROTEIN folding
- Publication
Revista Latinoamericana de Hipertension, 2024, Vol 19, Issue 4, p175
- ISSN
1856-4550
- Publication type
Article
- DOI
10.5281/zenodo.11261487