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- Title
Translocation (1;22)(p36;q11.2) with concurrent del(22)(q11.2) resulted in homozygous deletion ofSNF5/INI1in a newly established cell line derived from extrarenal rhabdoid tumor.
- Authors
Misawa, Akiko; Hosoi, Hajime; Imoto, Issei; Iehara, Tomoko; Sugimoto, Tohru; Inazawa, Johji
- Abstract
Malignant rhabdoid tumor (MRT) is a highly malignant pediatric cancer, which arises in various sites such as the kidney, brain, and soft tissues. Cytogenetic studies have revealed alterations of 22q11 in MRT. Recently, deletions and mutations of theSNF5/INI1locus in 22q11.2 have been reported in MRT, suggesting thatSNF5/INI1is a tumor suppressor gene for MRT. Here we report our molecular cytogenetic study for a newly established cell line from extrarenal MRT with t(1;22)(p36;q11.2). Consequently, the reciprocal translocation was associated with the interstitial deletion of a small segment includingSNF5/INI1, and another, chromosome 22, showed terminal deletion, the breakpoint of which was located 70-80 kb centromeric toSNF5/INI1, resulting in homozygous deletion ofSNF5/INI1in this cell line.
- Subjects
TUMORS; PATHOLOGY; CANCER; ONCOLOGY; CHILDHOOD cancer; TUMORS in children
- Publication
Journal of Human Genetics, 2004, Vol 49, Issue 10, p586
- ISSN
1434-5161
- Publication type
Article
- DOI
10.1007/s10038-004-0191-y